REGIOSELECTIVE DEMETHYLATION OF ACONITINE

被引：17

作者：

BLAGBROUGH, IS ^{[1
]}

HARDICK, DJ ^{[1
]}

WONNACOTT, S ^{[1
]}

POTTER, BVL ^{[1
]}

机构：

[1] UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76910-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective demethylation of aconitine has been achieved with Lewis acids. Me(3)SiI afforded first 18-O-desmethyl- and then 16,18-di-O-desmethylaconitine, but AlCl3/NaI gave 16-O-desmethylaconitine first. The acetate and benzoate esters survived throughout these procedures. Aconitine decomposed on treatment with BBr3.

引用

页码：3367 / 3370

页数：4

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