PHOTOTOXIC POTENTIAL OF QUINOLONES

被引：16
作者：
CARDENAS, AM
VARGAS, F
FERNANDEZ, E
HIDALGO, ME
机构：
[1] Laboratorio de Fotobiologia y Fotoquimica, Facultad de Medicina, Universidad de Valparaiso, Valparaiso
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1991年 / 10卷 / 03期
关键词：
QUINOLONES; PHOTOTOXICITY; PHOTOHEMOLYSIS; PHOTODYNAMIC; SINGLET OXYGEN;
D O I：
10.1016/1011-1344(91)85006-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The photohaemolytic potentials of the quinolones oxolinic acid, pipemidic acid, rosoxacin, norfloxacin, ciprofloxacin and M-193324 (synthesis intermediary) were evaluated and compared with the photohaemolysis induced by nalidixic acid. Quinolones with a piperazine group in position 7 (pipemidic acid, norfloxacin and ciprofloxacin) did not induce photohaemolysis. However, oxolinic acid, rosoxacin and M-193324 produced a concentration- and oxygen-dependent photohaemolysis. Ascorbic acid, histidine and thiourea inhibited the photohaemolysis induced by oxolinic acid, rosoxacin and M-193324, suggesting a photodynamic mechanism similar to that found with nalidixic acid. In addition, deuterium oxide increased the photohaemolysis induced by photohaemolytic quinolones, indicating that this process is mediated by singlet oxygen.
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页码：249 / 255
页数：7
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