G-308A polymorphism in the tumor necrosis factor-alpha gene in Buryats

被引：0
作者：
Dugarova, G. O. [1 ]
Golubenko, M., V [2 ]
Eremina, E. R. [3 ]
Minaycheva, L., I [4 ]
Fadyushina, S., V [5 ]
机构：
[1] Childrens Republican Clin Hosp, Moscow Childrens Clin Hosp, Ulan Ude, Russia
[2] Russian Acad Med Sci, Res Inst Med Genet, Siberian Branch, Tomsk, Russia
[3] SRI MGSS RAMS, Buryat Branch, Ulan Ude, Russia
[4] Res Inst MG SB RAMS, Tomsk, Russia
[5] MG SB RAMS, Moscow Res Inst, Moscow, Russia
来源：
YAKUT MEDICAL JOURNAL | 2009年 / 02期
关键词：
polymorphism; the tumor necrosis factor-alpha gene; Buryats;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
G-308A polymorphism in the tumor necrosis factor-alpha (TNF) gene has been studied in the Buryat population by genotyping samples from 16 subpopulations from 5 areas of Republic Buryatiya (N=865). The TNF-alpha G-308A polymorphism was assessed by the PCR and restriction analysis. It has been shown that frequency of the A allele in Buryats was 11.5 %. At comparison with other Siberian populations, statistically significant differences with Yakuts were found. In several subpopulations the deviation of genotype frequencies from Hardy-Weinberg equilibrium was revealed. Calculation of genetic differentiation measure for all settlements (Gst=0.0167) and for 5 investigated areas (Gst=0.0053) did not demonstrate significant differentiation of a gene pool of Buryats by the given polymorphism. The results give for Buryat population the characteristics of prevalence of functionally significant polymorphism for which associations with various multifactorial diseases are known.
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页码：127 / 129
页数：3
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