EFFECT OF DILTIAZEM SLOW-RELEASE FORMULATION ON SILENT-MYOCARDIAL-ISCHEMIA IN STABLE CORONARY-ARTERY DISEASE

被引：14
作者：
JUNEAU, M
THEROUX, P
WATERS, D
机构：
[1] Department of Medicine, Montreal Heart Institute, Montreal, Que.
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1992年 / 69卷 / 07期
关键词：
D O I：
10.1016/0002-9149(92)91347-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Silent myocardial ischemia is associated with adverse outcome in several subsets of coronary artery disease patients. This article presents results of a placebo-controlled, randomized, double-blind study of the effects of sustained-release diltiazem (180 mg twice daily) on ischemic episodes in 60 patients with documented coronary artery disease. The mean age of the study population was 60 years and 93% were male. The mean number of episodes of silent ischemia per patient was 5.6 (placebo) and 2.8 (diltiazem), a 50% reduction (p < 0.0001). Duration of ST-segment depression was 119 minutes (placebo) and 67 minutes (diltiazem), a 44% reduction (p < 0.001). This study demonstrates that sustained-release diltiazem can significantly reduce the frequency and total duration of silent ischemic episodes.
引用
收藏
页码：B30 / B35
页数：6
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