FORMATION OF TERNARY COMPLEXES INVOLVING ZINC OR COPPER IONS, POLYNUCLEOTIDES, AND POLYPEPTIDES CONTAINING GLUTAMIC-ACID AND TYROSINE RESIDUES

被引：31

作者：

BERE, A ^{[1
]}

HELENE, C ^{[1
]}

机构：

[1] MUSEUM NATL HIST NAT, BIOPHYS LAB, F-75231 PARIS 05, FRANCE

来源：

BIOPOLYMERS | 1979年 / 18卷 / 11期

关键词：

D O I：

10.1002/bip.1979.360181103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal ions such as Zn2+ and Cu2+ can mediate interactions between copolypeptides (Glux, Tyry)n and polynucleotides. CD data show that these ternary complexes are characterized by an unstacking of nucleic acid bases, while the polypeptide adopts an α‐helical conformation as observed in the two binary complexes polynucleotide–cation and polypeptide–cation. Fluorescence studies demonstrate that tyrosyl side chains interact with nucleic acid bases in the ternary complexes, leading to a quenching of tyrosine fluorescence. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：2659 / 2672

页数：14

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