INABILITY OF ENDOTHELIN TO INCREASE CA-2+ CURRENT IN GUINEA-PIG HEART-CELLS

被引：40

作者：

TOHSE, N

HATTORI, Y

NAKAYA, H

ENDOU, M

KANNO, M

机构：

[1] Department of Pharmacology, Hokkaido University, School of Medicine

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 99卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12944.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of endothelin, a novel vasoconstrictor peptide derived from vascular endothelial cells, on cardiac contractility and membrane currents, were examined in guinea-pig cardiac preparations. Endothelin (3-1000 nM) produced a positive inotropic effect in papillary muscles in a concentration-dependent manner. In whole-cell voltage clamp recording, endothelin (250 nM) decreased the amplitude of Ca2+ current (I(Ca), 25.0 ± 6.6%) in ventricular myocytes. The endothelin-induced decrease in I(Ca) was abolished by pretreatment with ryanodine (1 μM). These results suggest that endothelin does not activate cardiac sarcolemmal Ca2+ channels. The enhancement of the sarcoplasmic reticulum function may play an important role in the positive inotropic effect of endothelin.

引用

页码：437 / 438

页数：2

共 8 条

[1] THE FAILURE OF ENDOTHELIN TO DISPLACE BOUND, RADIOACTIVELY-LABELED, CALCIUM-ANTAGONISTS (PN 200/110, D888 AND DILTIAZEM) [J].