A sticky situation Untangling the transcriptional network controlling biofilm development in Candida albicans

被引：68
作者：
Fox, Emily P. [1 ,2 ]
Nobile, Clarissa J. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Biochem & Biophys, Tetrad Program, San Francisco, CA 94143 USA
来源：
TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 06期
关键词：
transcriptional regulation; transcription networks; biofilm development; Candida albicans;
D O I：
10.4161/trns.22281
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Candida albicans is a commensal microorganism of the human microbiome; it is also the most prevalent fungal pathogen of humans. Many infections caused by C. albicans are a direct consequence of its proclivity to form biofilms-resilient, surface-associated communities of cells where individual cells acquire specialized properties that are distinct from those observed in suspension cultures. We recently identified the transcriptional network that orchestrates the formation of biofilms in C. albicans. These results set the stage for understanding how biofilms are formed and, once formed, how the specialized properties of biofilms are elaborated. This information will provide new insight for understanding biofilms in more detail and may lead to improvements in preventing and treating biofilm-based infections in the future.
引用
收藏
页码：315 / 322
页数：8
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