MAKING MODELS FOR ALZHEIMERS-DISEASE

[1] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J]. CELL, 1994, 77 (06) : 817 - 827

[2] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J]. SCIENCE, 1993, 259 (5094) : 514 - 516

[3] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION [J]. NATURE, 1992, 360 (6405) : 672 - 674

[4] PROCESSING OF THE AMYLOID PROTEIN-PRECURSOR TO POTENTIALLY AMYLOIDOGENIC DERIVATIVES [J]. SCIENCE, 1992, 255 (5045) : 728 - 730

[5] AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM [J]. NATURE, 1992, 359 (6393) : 322 - 325

[6] TARGETING OF CELL-SURFACE BETA-AMYLOID PRECURSOR PROTEIN TO LYSOSOMES - ALTERNATIVE PROCESSING INTO AMYLOID-BEARING FRAGMENTS [J]. NATURE, 1992, 357 (6378) : 500 - 503

[7] A MODEL FOR BETA-AMYLOID AGGREGATION AND NEUROTOXICITY BASED ON FREE-RADICAL GENERATION BY THE PEPTIDE - RELEVANCE TO ALZHEIMER-DISEASE [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 3270 - 3274

[8] SEEDING ONE-DIMENSIONAL CRYSTALLIZATION OF AMYLOID - A PATHOGENIC MECHANISM IN ALZHEIMERS-DISEASE AND SCRAPIE [J]. CELL, 1993, 73 (06) : 1055 - 1058

[9] JUCKER M, 1992, SCIENCE, V255, P1443, DOI 10.1126/science.1542796

[10] DEPOSITION OF BETA/A4 IMMUNOREACTIVITY AND NEURONAL PATHOLOGY IN TRANSGENIC MICE EXPRESSING THE CARBOXYL-TERMINAL FRAGMENT OF THE ALZHEIMER AMYLOID PRECURSOR IN THE BRAIN [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) : 10857 - 10861

[1] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J]. CELL, 1994, 77 (06) : 817 - 827

[2] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J]. SCIENCE, 1993, 259 (5094) : 514 - 516

[3] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION [J]. NATURE, 1992, 360 (6405) : 672 - 674

[4] PROCESSING OF THE AMYLOID PROTEIN-PRECURSOR TO POTENTIALLY AMYLOIDOGENIC DERIVATIVES [J]. SCIENCE, 1992, 255 (5045) : 728 - 730

[5] AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM [J]. NATURE, 1992, 359 (6393) : 322 - 325

[6] TARGETING OF CELL-SURFACE BETA-AMYLOID PRECURSOR PROTEIN TO LYSOSOMES - ALTERNATIVE PROCESSING INTO AMYLOID-BEARING FRAGMENTS [J]. NATURE, 1992, 357 (6378) : 500 - 503

[7] A MODEL FOR BETA-AMYLOID AGGREGATION AND NEUROTOXICITY BASED ON FREE-RADICAL GENERATION BY THE PEPTIDE - RELEVANCE TO ALZHEIMER-DISEASE [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 3270 - 3274

[8] SEEDING ONE-DIMENSIONAL CRYSTALLIZATION OF AMYLOID - A PATHOGENIC MECHANISM IN ALZHEIMERS-DISEASE AND SCRAPIE [J]. CELL, 1993, 73 (06) : 1055 - 1058

[9] JUCKER M, 1992, SCIENCE, V255, P1443, DOI 10.1126/science.1542796

[10] DEPOSITION OF BETA/A4 IMMUNOREACTIVITY AND NEURONAL PATHOLOGY IN TRANSGENIC MICE EXPRESSING THE CARBOXYL-TERMINAL FRAGMENT OF THE ALZHEIMER AMYLOID PRECURSOR IN THE BRAIN [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) : 10857 - 10861