AMINO-ACID EFFECTS ON ETHANOL OXIDATION IN ISOLATED RAT-LIVER CELLS

被引：4

作者：

MANGENEY, M

BEAUGE, F

NORDMANN, J

NORDMANN, R

机构：

[1] FAC MED PARIS QUEST, SERV BIOCHIM, PARIS, FRANCE

[2] INSERM, RECH METAB INTERMED GRP, F-75005 PARIS, FRANCE

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1979年 / 87卷 / 03期

关键词：

D O I：

10.3109/13813457909070524

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of various naturally occurring amino acids on ethanol oxidation in hepatocytes from starved rats were systematically studied. To minimize the non alcohol dehydrogenase pathways, the ethanol concentration used was 4 mM and the amino acids were added at the same concentration. In hepatocytes from fasted rats, Ala, Arg, Asn, Asp, citrulline, Cys, Glu, Gln, Gly, His, hydroxyproline, Orn and Ser significantly increased ethanol consumption. Because the stimulatory effect of Glu was much less pronounced than Asn and Pro was devoid of action, the influence of ammonium chloride addition on ethanol consumption in the presence of these amino acids was studied. Ammonium chloride showed an enhancement of ethanol oxidation under these conditions. No apparent correlation between intracellular Glu concentration and ethanol oxidation rate was seen, contrary to previous data. In hepatocytes from fed rats, only Ala, Asn, Cys, Gly, hydroxyproline, Orn and Ser increased ethanol oxidation, although to a lesser extent than in cells from starved rats.

引用

页码：603 / 612

页数：10

共 24 条

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[3]

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[4]

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