STRUCTURE-ACTIVITY RELATIONSHIPS OF SOME 5-NITRO-2-FURALDEHYDE OXIMES AND HYDRAZONES

被引：5

作者：

HOWARTH, GA

HOYLE, W

机构：

[1] Pharmaceutical Research Laboratory, Geigy (U.K.) Ltd., Manchester, 17, Trafford Park

来源：

TALANTA | 1969年 / 16卷 / 07期

关键词：

D O I：

10.1016/0039-9140(69)80136-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

5-Nitro-2-furaldoxime, 5-nitro-2-furaldehyde hydrazone, and several derivatives have been prepared, and their stereochemistry studied by NMR. The relationship between the structures of the compounds and their in vitro and in vivo antimicrobial activity was investigated. © 1969.

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页码：967 / &

相关论文

共 16 条

[1] THE RELATIONSHIP OF STRUCTURE AND ANTIBACTERIAL ACTIVITY IN THE NITROFURANS [J].

DODD, MC ;

CRAMER, DL ;

WARD, WC .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION-SCIENTIFIC EDITION, 1950, 39 (06) :313-318

[2]

ELLIS GP, 1967, PROGRESS MEDICINAL C, V5

[3] NITROFURALDOXIMES - SEPARATION OF ISOMERS BY UREA COMPLEX FORMATION [J].

GEVER, G .

JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (05) :754-754

[4]

HOWARTH GA, 1968, Patent No. 1108397

[5]

HULL R, 1959, Patent No. 816886

[6]

IKEDA M, 1953, ANN REPT FAC PHARM K, V3, P25

[7] STRUCTURAL STUDIES BY NUCLEAR MAGNETIC RESONANCE .17. CONFORMATIONS AND CONFIGURATIONS OF N-METHYLHYDRAZONES [J].

KARABATSOS, GJ ;

TALLER, RA .

TETRAHEDRON, 1968, 24 (09) :3557-+

[8] STRUCTURAL STUDIES BY NUCLEAR MAGNETIC RESONANCE .11. CONFORMATIONS AND CONFIGURATIONS OF OXIME O-METHYL ETHERS [J].

KARABATSOS, GJ ;

HSI, N .

TETRAHEDRON, 1967, 23 (03) :1079-+

[9]

Kawabe K., 1960, YAKUGAKU ZASSHI, V80, P65

[10] ANTIBACTERIAL NITROFURAN DERIVATIVES .I. 5-NITRO-2-FURALDEHYDE SEMICARBAZONES AND THIOSEMICARBAZONES [J].

NARDI, D ;

MASSARAN.E ;

TAJANA, A ;

DEGEN, L ;

MAGISTRE.MJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (04) :530-&