THE ROLE OF BSAP (PAX-5) IN B-CELL DEVELOPMENT

被引：72
作者：
BUSSLINGER, M
URBANEK, P
机构：
[1] Research Institute of Molecular Pathology, A-1030 Vienna
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0959-437X(95)80028-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
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收藏
页码：595 / 601
页数：7
相关论文
共 53 条
[1]   PAX-5 ENCODES THE TRANSCRIPTION FACTOR BSAP AND IS EXPRESSED IN LYMPHOCYTES-B, THE DEVELOPING CNS, AND ADULT TESTIS [J].
ADAMS, B ;
DORFLER, P ;
AGUZZI, A ;
KOZMIK, Z ;
URBANEK, P ;
MAURERFOGY, I ;
BUSSLINGER, M .
GENES & DEVELOPMENT, 1992, 6 (09) :1589-1607
[2]   LIPOPOLYSACCHARIDE-DEPENDENT TRANSACTIVATION OF THE TEMPORALLY REGULATED IMMUNOGLOBULIN HEAVY-CHAIN 3' ENHANCER [J].
ARULAMPALAM, V ;
GRANT, PA ;
SAMUELSSON, A ;
LENDAHL, U ;
PETTERSSON, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (07) :1671-1677
[3]   E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].
BAIN, G ;
MAANDAG, ECR ;
IZON, DJ ;
AMSEN, D ;
KRUISBEEK, AM ;
WEINTRAUB, BC ;
KROP, I ;
SCHLISSEL, MS ;
FEENEY, AJ ;
VANROON, M ;
VANDERVALK, M ;
TERIELE, HPJ ;
BERNS, A ;
MURRE, C .
CELL, 1994, 79 (05) :885-892
[4]   DEVELOPMENTAL AND TISSUE-SPECIFIC REGULATION OF A NOVEL TRANSCRIPTION FACTOR OF THE SEA-URCHIN [J].
BARBERIS, A ;
SUPERTIFURGA, G ;
VITELLI, L ;
KEMLER, I ;
BUSSLINGER, M .
GENES & DEVELOPMENT, 1989, 3 (05) :663-675
[5]   A NOVEL B-CELL LINEAGE-SPECIFIC TRANSCRIPTION FACTOR PRESENT AT EARLY BUT NOT LATE STAGES OF DIFFERENTIATION [J].
BARBERIS, A ;
WIDENHORN, K ;
VITELLI, L ;
BUSSLINGER, M .
GENES & DEVELOPMENT, 1990, 4 (05) :849-859
[6]   CD19 - LOWERING THE THRESHOLD FOR ANTIGEN RECEPTOR STIMULATION OF LYMPHOCYTES-B [J].
CARTER, RH ;
FEARON, DT .
SCIENCE, 1992, 256 (5053) :105-107
[7]   MECHANISM AND REGULATION OF IMMUNOGLOBULIN ISOTYPE SWITCHING [J].
COFFMAN, RL ;
LEBMAN, DA ;
ROTHMAN, P .
ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 :229-270
[8]   CLASS SWITCH CONTROL REGION AT THE 3' END OF THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS [J].
COGNE, M ;
LANSFORD, TR ;
BOTTARO, A ;
ZHANG, J ;
GORMAN, J ;
YOUNG, F ;
CHENG, HL ;
ALT, FW .
CELL, 1994, 77 (05) :737-747
[9]   OCT-2, ALTHOUGH NOT REQUIRED FOR EARLY B-CELL DEVELOPMENT, IS CRITICAL FOR LATER B-CELL MATURATION AND FOR POSTNATAL SURVIVAL [J].
CORCORAN, LM ;
KARVELAS, M ;
NOSSAL, GJV ;
YE, ZS ;
JACKS, T ;
BALTIMORE, D .
GENES & DEVELOPMENT, 1993, 7 (04) :570-582
[10]  
CZERNY T, 1995, MOL CELL BIOL, V15, P2858
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