MW PHARM, AN INTEGRATED SOFTWARE PACKAGE FOR DRUG-DOSAGE REGIMEN CALCULATION AND THERAPEUTIC DRUG-MONITORING

被引：305

作者：

PROOST, JH

MEIJER, DKF

机构：

[1] Department of Pharmacology and Therapeutics, University Centre for Pharmacy, University of Groningen, 9713 AW Groningen

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1992年 / 22卷 / 03期

关键词：

CLINICAL PHARMACOKINETICS; DRUG DOSING; THERAPEUTIC DRUG MONITORING; BAYESIAN PARAMETER ESTIMATION; CURVE-FITTING; KIDNEY FUNCTION; BIOAVAILABILITY; BIOEQUIVALENCE;

D O I：

10.1016/0010-4825(92)90011-B

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The pharmacokinetic software package MW/Pharm offers an interactive, user-friendly program which gives rapid answers in clinical practice. It comprises a database with pharmacokinetic parameters of 180 drugs, a medication history database, and procedures for an individual drug dosage regimen calculation. The included curve-fitting facilities allow estimation of pharmacokinetic parameters on the basis of medication history, taking into account a varying status of the patient with respect to body weight and kidney function, optionally using a Bayesian procedure. The module KinBes performs the evaluation of bioavailability studies, including various methods, and an extensive statistical evaluation of bioequivalence.

引用

页码：155 / 163

页数：9