MW PHARM, AN INTEGRATED SOFTWARE PACKAGE FOR DRUG-DOSAGE REGIMEN CALCULATION AND THERAPEUTIC DRUG-MONITORING

被引：305
作者：
PROOST, JH
MEIJER, DKF
机构：
[1] Department of Pharmacology and Therapeutics, University Centre for Pharmacy, University of Groningen, 9713 AW Groningen
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 1992年 / 22卷 / 03期
关键词：
CLINICAL PHARMACOKINETICS; DRUG DOSING; THERAPEUTIC DRUG MONITORING; BAYESIAN PARAMETER ESTIMATION; CURVE-FITTING; KIDNEY FUNCTION; BIOAVAILABILITY; BIOEQUIVALENCE;
D O I：
10.1016/0010-4825(92)90011-B
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The pharmacokinetic software package MW/Pharm offers an interactive, user-friendly program which gives rapid answers in clinical practice. It comprises a database with pharmacokinetic parameters of 180 drugs, a medication history database, and procedures for an individual drug dosage regimen calculation. The included curve-fitting facilities allow estimation of pharmacokinetic parameters on the basis of medication history, taking into account a varying status of the patient with respect to body weight and kidney function, optionally using a Bayesian procedure. The module KinBes performs the evaluation of bioavailability studies, including various methods, and an extensive statistical evaluation of bioequivalence.
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收藏
页码：155 / 163
页数：9
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