MODULATION OF CORTICAL INVIVO ACETYLCHOLINE-RELEASE BY THE BASAL NUCLEAR-COMPLEX - ROLE OF THE PONTOMESENCEPHALIC TEGMENTAL AREA

被引：34

作者：

BERTORELLI, R ^{[1
]}

FORLONI, G ^{[1
]}

CONSOLO, S ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES, CHOLINERG NEUROPHARMACOL LAB, VIA ERITREA 62, I-20157 MILAN, ITALY

来源：

BRAIN RESEARCH | 1991年 / 563卷 / 1-2期

关键词：

SCOPOLAMINE; PICROTOXIN; OXOTREMORINE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS LESION; BASOCORTICAL PATHWAY; MICRODIALYSIS;

D O I：

10.1016/0006-8993(91)91562-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acetylcholine (ACh) release in vivo from rat cortices was determined by microdialysis either after injection of drugs into the basal nuclear complex (NBM) or after electrolytic lesion of the pontomesencephalic tegmental nucleus (PPT). Scopolamine (SCOP) (5-10-mu-g) increased and oxotremorine (10-mu-g) reduced cortical ACh release, indicating that an inhibitory mechanism operates within the area. The gamma-aminobutyric acid (GABA)ergic antagonist, picrotoxin (2.5-mu-g), by disinhibiting the cholinergic basocortical neurons, induced an increase that was not affected by SCOP. Acute lesion of the cholinergic PPT efferents to NBM raised cortical basal release. Thus, ACh released from the PPT terminals apparently modulates the function of basocortical neurons mainly through a polysynaptic link via GABAergic neurons.

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页码：353 / 356

页数：4

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