EFFECTS OF ANTICHOLINERGIC DRUGS ON RABBIT EFFERENT PHRENIC DISCHARGES

被引：0

作者：

BIAN, CF

ZHOU, J

HONG, XM

YIN, XX

机构：

来源：

ACTA PHARMACOLOGICA SINICA | 1991年 / 12卷 / 04期

关键词：

RESPIRATORY CENTER; PHRENIC NERVE; ELECTROPHYSIOLOGY; SCOPOLAMINE; PIRENZEPINE; ATROPINE; BENZODIAZEPINES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In conscious, vagotomized, curarized, and artificially-ventilated rabbits, the efferent phrenic discharges were recorded. When scopolamine, atropine, pirenzepine or AF-DX 116 (11-2[[2-[(diethylamino)methyl]-piperidinyl]acetyl] -5,11-dihydro-6H[2,3-6] [1,4]benzodiazepine-6-one) was injected into the cerebello-medullary cistern, the frequency and voltage of phrenic discharges were decreased (P < 0.05) by scopolamine (0.5 mg.kg-1) and pirenzepine (0.5 mg.kg-1), but were increased (P < 0.01) by atropine (0.05 mg.kg-1) and AF-DX 116 (0.1 mg.kg-1). It is probable that scopolamine inhibits the respiratory center by blocking the M1 cholinergic receptors while atropine excites the respiratory center blocking the M2 cholinergic receptors.

引用

页码：294 / 297

页数：4

共 7 条

[1]

BIAN CF, 1987, ACTA PHARMACOL SIN, V8, P396

[2] DISTRIBUTION OF MUSCARINIC RECEPTOR SUBTYPES IN RAT-BRAIN AS DETERMINED IN BINDING-STUDIES WITH AF-DX 116 AND PIRENZEPINE [J].