LOCALIZATION OF MURINE IG-1B AND IG-1A (IGG 2A) ALLOTYPIC DETERMINANTS DETECTED WITH MONOCLONAL ANTIBODIES

被引：157

作者：

OI, VT

HERZENBERG, LA

机构：

[1] Department of Genetics, Stanford University School of Medicine, Stanford

来源：

MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 12期

关键词：

D O I：

10.1016/0161-5890(79)90034-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used hybridoma anti-allotype antibodies to define six allotypic determinants: four on Ig-1b molecules and two on Ig-1a molecules. By locating these determinants on fragments obtained by limited proteolysis of IgG2a, molecules and by hybridoma antibody blocking assays, five distinct allotypic sites have been defined on mouse γ2a heavy chains. These sites are located in the hinge region and the CH2 and CH3 domains. We have not been able to show genetic recombination between these sites by genetic linkage studies. © 1979.

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页码：1005 / 1017

页数：13

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