POLYAMINES AND CELLULAR ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE

被引：22

作者：

CLO, C ^{[1
]}

CALDARERA, CM ^{[1
]}

TANTINI, B ^{[1
]}

BENALAL, D ^{[1
]}

BACHRACH, U ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH HOSP & MED SCH,DEPT MOLEC BIOL,JERUSALEM,ISRAEL

来源：

BIOCHEMICAL JOURNAL | 1979年 / 182卷 / 03期

关键词：

D O I：

10.1042/bj1820641a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of polyamines on the cellular concentrations of cyclic AMP was studied. It was shown that 1 μm-spermene caused a decrease in cyclic AMP in chick-embryo heart cells, chick-embryo fibroblasts, neuroblastoma, glioma and neuroblastoma-glioma hybrid cells, grown in culture. A similar decrease was observed when polyamines were added to cells in the presence of a phosphodiesterase inhibitor or after stimulating the cells with various hormones. Noradrenaline was used in cultures of heart cells, prostaglandin E1 and adenosine for neuroblastoma and neuroblastoma-glioma hybrids, whereas isoproterenol was used for the stimulation of glioma cells. Polyamines at higher concentrations were either without effect or caused a slight increase in cyclic AMP. Spermidine (10 μm) also caused a decreased in cellular cyclic AMP, as did 0.1 μm-putrescine. It is suggested that the effect of polyamines on cellular cyclic AMP may be explained by the effect of these polycations on the activity of cellular phosphodiesterase.

引用

页码：641 / 649

页数：9

共 51 条

[1] ADENYLATE CYCLASES IN PHYSARUM-POLYCEPHALUM - INHIBITION OF A NUCLEAR ENZYME BY POLYAMINES
ATMAR, VJ
WESTLAND, JA
GARCIA, G
KUEHN, GD
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 68 (02) : 561 - 568
[2] CYCLIC AMP-MEDIATED INDUCTION OF ORNITHINE DECARBOXYLASE OF GLIOMA AND NEUROBLASTOMA-CELLS
BACHRACH, U
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) : 3087 - 3091
[3] POLYAMINES AND PROTEIN-KINASE .1. INDUCTION OF ORNITHINE DECARBOXYLASE AND ACTIVATION OF PROTEIN-KINASE IN RAT GLIOMA CELLS
BACHRACH, U
KATZ, A
HOCHMAN, J
[J]. LIFE SCIENCES, 1978, 22 (09) : 817 - 822
[4] POLYAMINES AND NEOPLASTIC GROWTH - STABILIZATION OF ORNITHINE DECARBOXYLASE DURING TRANSFORMATION
BACHRACH, U
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 72 (03) : 1008 - 1013
[5] BACHRACH U, 1973, FUNCTION NATURALLY O, P74
[6] BLASCHKO H., 1962, ADVANCES COMP PHYSIOL AND BIOCHEM, V1, P67
[7] CAMP AND CELL CYCLE - INHIBITION OF GROWTH STIMULATION
BOMBIK, BM
BURGER, MM
[J]. EXPERIMENTAL CELL RESEARCH, 1973, 80 (01) : 88 - 94
[8] ORNITHINE DECARBOXYLASE ACTIVITY - CONTROL BY CYCLIC NUCLEOTIDES
BYUS, CV
RUSSELL, DH
[J]. SCIENCE, 1975, 187 (4177) : 650 - 652
[9] CALDARERA CM, 1976, ITAL J BIOCHEM, V25, P33
[10] POLYAMINES AND NUCLEIC ACID METABOLISM IN CHICK EMBRYO
CALDARERA, CM
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1970, 171 (03) : 709 - +

← 1 2 3 4 5 6 →