Potential anticancer agents. XXXVI. Alkylating agents derived from 5-aminouracil

Two monofunctional alkylating agents, 5-(2-chloroethylamino)-uracil (V) and 5-12-chloroethyl)-ethylamino]-uracil (VIII), were synthesized for comparison of effectiveness as antitumor compounds with difunctional alkylating agents. An unknown material, obtained via the hydroxyethylation of 5-(ethylamino)-uracil (III), was identified as 3-(2-chloroethvl)-5-[(2-chloroethyl)-ethylaminol-uracil (XIIa) by comparison of its ultraviolet spectra with those of the previously unknown compounds, 5-[bis-(2-chloroethyl)-aminol-3-methyluracil (XVIII) and 5-[bis-(2-cliloroethyl)-amino]-1-methyluracil (XXVI).