ANTICONVULSANT PROPERTIES OF PROPOFOL AND THIOPENTONE - COMPARISON USING 2 TESTS IN LABORATORY MICE

被引：99

作者：

LOWSON, S

GENT, JP

GOODCHILD, CS

机构：

[1] UNIV LEEDS,DEPT CYTOPHARMACOL,24 HYDE TERRACE,LEEDS LS2 9LN,W YORKSHIRE,ENGLAND

[2] GEN INFIRM,DEPT ANAESTHESIA,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[3] UNIV LEEDS,DEPT PHARMACOL,LEEDS LS2 9LN,W YORKSHIRE,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 01期

关键词：

Anaesthetics i.v.: propofol; thiopentone; Anticonvulsants;

D O I：

10.1093/bja/64.1.59

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Experiments were carried out in mice to assess the protection provided by thiopentone (Intraval, May and Baker) and propofol (Diprivan, I.C.I.) against epileptiform seizures induced by electro-shock and pentylenetetrazol. Intraperitoneal administration of propofol 50 mg kg-1 and thiopentone 25 mg kg-1 produced similar peak behavioural effects of mild sedation and incoordination. However, at these doses propofol afforded a greater degree of protection against pentylenetetrazol than thiopentone and at greater doses both propofol and thiopentone caused marked protection. Both anaesthetics were effective also against electroshock seizures at sedative doses. We conclude that propofol has strong anticonvulsant properties. © 1990 Copyright: 1990 British Journal of Anaesthesia.

引用

页码：59 / 63

页数：5

共 13 条

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