Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives

被引：29

作者：

Aguilar, Fernando ^{[1
]}

Crebelli, Riccardo ^{[1
]}

Di Domenico, Alessandro ^{[1
]}

Dusemund, Birgit ^{[1
]}

Frutos, Maria Jose ^{[1
]}

Galtier, Pierre ^{[1
]}

Gott, David ^{[1
]}

Gundert-Remy, Ursula ^{[1
]}

lambre, Claude ^{[1
]}

Leblanc, Jean-Charles ^{[1
]}

Lindtner, Oliver ^{[1
]}

Moldeus, Peter ^{[1
]}

Mortensen, Alicja ^{[1
]}

Mosesso, Pasquale ^{[1
]}

Parent-Massin, Dominique ^{[1
]}

Oskarsson, Agneta ^{[1
]}

Stankovic, Ivan ^{[1
]}

Waalkens-Berendsen, Ine ^{[1
]}

Woutersen, Rudolf Antonius ^{[1
]}

Wright, Matthew ^{[1
]}

Younes, Maged ^{[1
]}

机构：

[1] European Food Safety Author, Parma, Italy

来源：

EFSA JOURNAL | 2014年 / 12卷 / 07期

关键词：

Propionic acid; CAS; 70-09-4; E; 280; sodium propionate; 137-40-6; 281; calcium propionate; 4075-81-4; 282; potassium propionate; 327-62-8; 283;

D O I：

10.2903/j.efsa.2014.3779

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The EFSA ANS Panel provides a scientific opinion re-evaluating the safety of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) which are authorised as food additives in the EU and have been previously evaluated by the SCF and JECFA. JECFA allocated an ADI "not limited". The SCF concluded that potassium propionate could be added to the list of preservatives and established an ADI "not specified". Propionates are naturally occurring substances in the normal diet. The Panel considered that forestomach hyperplasia reported in long-term studies in rodents is not a relevant endpoint for humans because humans lack this organ. Based on the reported presence of reversible diffuse epithelial hyperplasia in the oesophagus the LOAEL for a 90-day study in dogs was considered by the Panel to be 1 % propionic acid in the diet and the NOAEL to be 0.3 % propionic acid in the diet. The Panel considered that there is no concern with respect to genotoxicity and carcinogenicity. The Panel concluded that the present database did not allow allocation of an ADI for propionic acid - propionates. The overall mean and 95th percentile exposures to propionic acid - propionates resulting from their use as food additives (major contributor to exposure) ranged from 0.7-21.1 and 3.6-40.8 mg/kg bw/day, respectively. The Panel noted that the concentration provoking site of contact effect in the 90-day study in dogs (1 % propionic acid in the diet) is a factor of three higher than the concentration of propionic acid - propionates in food at the highest permitted level and concluded that for food as consumed, there would not be a safety concern from the maximum concentrations of propionic acid and its salts at their currently authorised uses and use levels as food additives. (C) European Food Safety Authority, 2014

引用

页数：45

共 87 条

[1] Scientific Opinion on safety and efficacy of sodium benzoate, propionic acid and sodium propionate for pigs, poultry, bovines, sheep, goats, rabbits, horses [J].