Normal Macular Thickness in Healthy Indian Eyes Using Spectral Domain Optical Coherence Tomography

Purpose: To determine macular thickness and its variation with age and sex in healthy Indian eyes using Zeiss spectral domain optical coherence tomography (SD-OCT). Design: A prospective, cross-sectional study. Methods: Four hundred healthy adult subjects (>= 18 years) underwent macular cube scanning using Zeiss SD-OCT. Macular thickness from all 9 regions of the Early Treatment Diabetic Retinopathy Study map was documented for each subject. Variations in macular thickness by age and sex were determined. Results: The mean age of the subjects was 38.05 +/- 12.13 (range, 18-78) years. The mean ages in men and women were 39.19 +/- 12.16 and 37.13 +/- 12.05 years, respectively (P > 0.05). The mean central subfield thickness (CST) of all subjects was 240.40 +/- 18.26 mu m, and mean macular thickness was 287.87 +/- 18.07 mu m. The mean CST in the right and left eyes were 240.40 +/- 18.25 mu m and 239.65 +/- 17.73 mu m, respectively (P = 0.55). Males were associated with greater mean CST and mean macular thickness compared with females (P < 0.05). There was an association of mean CST with sex (adjusted r(2) = 0.095; P < 0.05) but not with age. Overall, the nasal quadrant was the thickest followed by the superior, inferior, and temporal subfields. Conclusions: This is the normative data for macular thickness in healthy Indian eyes using Zeiss SD-OCT. This will serve as a baseline for diagnosing and treating macular pathologies in Indian eyes because such data using Zeiss SD-OCT in Indian eyes have previously been lacking.