Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases

被引：15

作者：

Prosser, Suzanna L. ^{[1
]}

O'Regan, Laura ^{[2
]}

Fry, Andrew M. ^{[2
]}

机构：

[1] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[2] Univ Leicester, Dept Biochem, Leicester, Leics, England

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 03期

关键词：

Centrosome separation; mitosis; spindle assembly; Nek5; Nek6; Hsp72;

D O I：

10.1080/23723556.2015.1062952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mitotic spindle is the apparatus upon which chromosomes are segregated during cell division. We have discovered new roles for two members of the NIMA-related kinase (NEK) family in different molecular processes of spindle assembly. Moreover, loss of these proteins leads to segregation errors that drive cancer progression.

引用

页数：4

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