CKD (chronic kidney failure) is described as the gradual loss of kidney function. Based on e-GFR, CKD failure is classified under 5 stages . Hence Pharmacist can contribute in the management and rational drug usage management by providing general awareness to the clinicians regarding the importance of dose adjustment and usage in CKD patients Assessment of CKD patient's treatment pattern. This is a retrospective, prospective, &observational study conducted in CKD patients over a period of 6 months. The relevant information were collected in a structured data collection form and data were analyzed by using descriptive statistics. A total of 125 patients cases have been analyzed .the age group was between 21-90 years,69.6% were males and 30.4% were females; mean [Standard deviation(SD)] urea level was 107.14mg/dL,mean (SD) creatinine level was 5.51 mg/dL; 58.4% were in stage 5 The most commonly seen co-morbities were HTN, followed by T2DM,ANEMIA,IHD. The most commonly prescribed drugs were antihypertensive (183), diuretics (121), antiulcers (98) and antibiotics (97).64 drug interactions were found and 20 dose adjustments were intervened. This study clearly showed that there were significant medication related problems such as drug interactions, dose adjustment requirements and presence of more than 1 of co-morbities were observed. This study also focused that the Pharmacist contributions become importance in promotion of rational use of drugs.