Optogenetics to restore neural circuit function in Parkinson's disease

被引：7
作者：
Yoon, Hyung Ho [1 ]
Min, Joongkee [1 ]
Jeon, Sang Ryong [1 ]
机构：
[1] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Neurol Surg, Seoul 05505, South Korea
来源：
JOURNAL OF NEURORESTORATOLOGY | 2018年 / 6卷
关键词：
deep brain stimulation; optogenetics; neural circuit; Parkinson disease;
D O I：
10.26599/JNR.2018.9040007
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Deep brain stimulation surgery has been performed in various movement disorders and psychiatric diseases. However, electrical stimulation may unexpectedly affect other types of adjacent neurons outside of the target area. Recently, optogenetics has provided the opportunity to modulate specific target neurons. Since this novel technique can individually control specific neurons in freely moving animals, it could be proposed to restore neural circuit function to related diseases, such as affective disorders, Huntington's disease (HD), and Parkinson's disease (PD). Herein, we discuss how optogenetics works as a treatment for Parkinson's disease and other neural circuit dysfunctions.
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收藏
页码：88 / 92
页数：5
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