EVALUATION OF RETINOIDS AS THERAPEUTIC AGENTS IN DERMATOLOGY

被引：17
|
作者：
LEWIN, AH [1 ]
BOS, ME [1 ]
ZUSI, FC [1 ]
NAIR, X [1 ]
WHITING, G [1 ]
BOUQUIN, P [1 ]
TETRAULT, G [1 ]
CARROLL, FI [1 ]
机构：
[1] BRISTOL MYERS SQUIBB CO,DIV PHARMACEUT RES & DEV,DERMATOL RES,BUFFALO,NY 14213
来源：
PHARMACEUTICAL RESEARCH | 1994年 / 11卷 / 02期
关键词：
RETINOIDS; ANTIHYPERKERATINIZATION; ANTIHYPERPROLIFERATION; ANTIHYPERACTIVE SEBACIOUS GLAND; HYPERVITAMINOSIS A;
D O I：
10.1023/A:1018938920796
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.
引用
收藏
页码：192 / 200
页数：9
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