EVALUATION OF RETINOIDS AS THERAPEUTIC AGENTS IN DERMATOLOGY

被引：17

作者：

LEWIN, AH ^{[1
]}

BOS, ME ^{[1
]}

ZUSI, FC ^{[1
]}

NAIR, X ^{[1
]}

WHITING, G ^{[1
]}

BOUQUIN, P ^{[1
]}

TETRAULT, G ^{[1
]}

CARROLL, FI ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,DIV PHARMACEUT RES & DEV,DERMATOL RES,BUFFALO,NY 14213

来源：

PHARMACEUTICAL RESEARCH | 1994年 / 11卷 / 02期

关键词：

RETINOIDS; ANTIHYPERKERATINIZATION; ANTIHYPERPROLIFERATION; ANTIHYPERACTIVE SEBACIOUS GLAND; HYPERVITAMINOSIS A;

D O I：

10.1023/A:1018938920796

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.

引用

页码：192 / 200

页数：9

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