SERUM MACROPHAGE-COLONY-STIMULATING FACTOR (M-CSF) LEVELS CORRELATE WITH CLINICAL-RESPONSE TO INTERFERON-ALPHA IN PATIENTS WITH EARLY-STAGE B-CLL

被引：9

作者：

JEWELL, AP

YONG, KL

WORMAN, CP

TSAKONA, CP

GILES, FJ

GOLDSTONE, AH

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT HAEMATOL,LONDON WC1E 6HX,ENGLAND

[2] UNIV COLL & MIDDLESEX SCH MED,DEPT IMMUNOL,LONDON W1P 9PG,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 02期

关键词：

IFN-ALPHA; M-CSF; CLL; SERUM;

D O I：

10.1111/j.1365-2141.1994.tb04766.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interferon-alpha (IFN-alpha) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-alpha therapy, peripheral lymphocyte counts fell to 61.7 +/- 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 +/- 183 U/ml to 686 +/- 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-alpha in early-stage CLL.

引用

页码：441 / 443

页数：3

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