THE PHARMACOKINETICS OF OXYCODONE AFTER INTRAVENOUS-INJECTION IN ADULTS

被引：97

作者：

POYHIA, R

OLKKOLA, KT

SEPPALA, T

KALSO, E

机构：

[1] NATL PUBL HLTH INST,DEPT BIOCHEM,SF-00280 HELSINKI 28,FINLAND

[2] UNIV HELSINKI,DEPT CLIN PHARMACOL,SF-00290 HELSINKI 29,FINLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 32卷 / 04期

关键词：

OXYCODONE; OXYMORPHONE; NOROXYCODONE; PHARMACOKINETICS;

D O I：

10.1111/j.1365-2125.1991.tb03942.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and V(ss) were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.

引用

收藏

页码：516 / 518

页数：3

相关论文

共 10 条

[1]

Akaike H., 1976, MATH SCI, V14, P5

[2] DETERMINATION OF OXYCODONE AND A MAJOR METABOLITE IN URINE BY ELECTRON-CAPTURE GLC [J].

BASELT, RC ;

STEWART, CB .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1978, 2 (03) :107-109

[3] THE BIOAVAILABILITY AND PHARMACOKINETICS OF MORPHINE AFTER INTRAVENOUS, ORAL AND BUCCAL ADMINISTRATION IN HEALTHY-VOLUNTEERS [J].

HOSKIN, PJ ;

HANKS, GW ;

AHERNE, GW ;

CHAPMAN, D ;

LITTLETON, P ;

FILSHIE, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 27 (04) :499-505

[4] MORPHINE AND OXYCODONE IN THE MANAGEMENT OF CANCER PAIN - PLASMA-LEVELS DETERMINED BY CHEMICAL AND RADIORECEPTOR ASSAYS [J].

KALSO, E ;

VAINIO, A ;

MATTILA, MJ ;

ROSENBERG, PH ;

SEPPALA, T .

PHARMACOLOGY & TOXICOLOGY, 1990, 67 (04) :322-328

[5]

KALSO E, 1991, IN PRESS ACTA ANAEST

[6] MORPHINE AND METABOLITE BEHAVIOR AFTER DIFFERENT ROUTES OF MORPHINE ADMINISTRATION - DEMONSTRATION OF THE IMPORTANCE OF THE ACTIVE METABOLITE MORPHINE-6-GLUCURONIDE [J].

OSBORNE, R ;

JOEL, S ;

TREW, D ;

SLEVIN, M .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1990, 47 (01) :12-19

[7] PSYCHOMOTOR, RESPIRATORY AND NEUROENDOCRINOLOGICAL EFFECTS OF A MU-OPIOID RECEPTOR AGONIST (OXYCODONE) IN HEALTHY-VOLUNTEERS [J].

SAARIALHOKERE, U ;

MATTILA, MJ ;

SEPPALA, T .

PHARMACOLOGY & TOXICOLOGY, 1989, 65 (04) :252-257

[8] LINEAR PHARMACOKINETIC EQUATIONS ALLOWING DIRECT CALCULATION OF MANY NEEDED PHARMACOKINETIC PARAMETERS FROM COEFFICIENTS AND EXPONENTS OF POLYEXPONENTIAL EQUATIONS WHICH HAVE BEEN FITTED TO DATA [J].

WAGNER, JG .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1976, 4 (05) :443-467

[9]

WEINSTEIN SH, 1979, J PHARM SCI, V68, P527, DOI 10.1002/jps.2600680441

[10]

SYSTAT SYSTEM STATIS