NEW HYBRID TRANSITION-STATE ANALOG INHIBITORS OF HIV PROTEASE WITH PERIPHERAL C2-SYMMETRY

被引：440

作者：

STOWASSER, B

BUDT, KH

LI, JQ

PEYMAN, A

RUPPERT, D

机构：

[1] Hoechst AG, Forschung G 838

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)61002-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel hybrid transition state analogs, a combination of phosphinic acid- and hydroxymethylene-type inhibitors of HIV protease, is demonstrated. These nonsymmetrical structures, placed in a peripheric C2-symmetrical environment, inhibit HIV protease in the lower nanomolar range.

引用

页码：6625 / 6628

页数：4

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