TOTAL SYNTHESIS OF (+/-)-CITREOVIRAL, BASED ON A BIOGENETIC MODEL, AND FORMAL SYNTHESIS OF (+/-)-CITREOVIRIDIN

被引：12
作者：
BOWDEN, MC [1 ]
PATEL, P [1 ]
PATTENDEN, G [1 ]
机构：
[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 08期
关键词：
D O I：
10.1039/p19910001947
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of (+/-)-citreoviral, which co-occurs with citreoviridin, citreoviridinol, and citreodiol in Penicillium citreoviride, is described. The synthesis is based on a biogenetic model, and has as a key feature the elaboration of the dihydroxytetrahydrofuranyl ring portion 10 by an acid-catalysed cyclisation of the central epoxy alcohol intermediate 9 which is derived in ten steps from methyl tiglate.
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页码：1947 / 1950
页数：4
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