QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION OF [I-125] ENDOTHELIN-1 BINDING-SITES IN SPINAL-CORD AND DORSAL-ROOT GANGLIA OF THE RAT

被引：31
|
作者：
KAR, S
CHABOT, JG
QUIRION, R [1 ]
机构：
[1] MCGILL UNIV,DOUGLAS HOSP,RES CTR,6875 LA SALLE BLVD,VERDUN H4H 1R3,QUEBEC,CANADA
[2] MCGILL UNIV,DEPT PSYCHIAT,VERDUN,QUEBEC,CANADA
来源：
NEUROSCIENCE LETTERS | 1991年 / 133卷 / 01期
关键词：
RECEPTOR AUTORADIOGRAPHY; ENDOTHELIN-1; RAT; SPINAL CORD; DORSAL ROOT GANGLIA; DEVELOPMENT;
D O I：
10.1016/0304-3940(91)90071-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The autoradiographic distribution of [I-125] endothelin (ET)-1 binding sites was studied in the spinal cord and dorsal root ganglia of developing and adult rat. In the spinal cord, high density of [I-125]ET-1 binding sites were diffusely distributed throughout the grey matter whereas in the ganglia discrete silver grains were localised primarily on the satellite cells. A variation in the density of binding sites was evident, particularly in the spinal cord, during development. These data, in conjunction with other reports, suggest a possible neuromodulatory role for ET-1 in spinal cord and dorsal root ganglia of the rat.
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页码：117 / 120
页数：4
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