CYCLICAL CUSHINGS-DISEASE AND ITS SUCCESSFUL CONTROL UNDER SODIUM VALPROATE

被引：37

作者：

BECKERS, A ^{[1
]}

STEVENAERT, A ^{[1
]}

PIRENS, G ^{[1
]}

FLANDROY, P ^{[1
]}

SULON, J ^{[1
]}

HENNEN, G ^{[1
]}

机构：

[1] UNIV LIEGE, B-4000 LIEGE, BELGIUM

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1990年 / 13卷 / 11期

关键词：

CYCLICAL CUSHINGS DISEASE; SODIUM VALPROATE; HYPOTHALAMUS;

D O I：

10.1007/BF03349657

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent trans-sphenodial surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin.

引用

页码：923 / 929

页数：7

共 28 条

[1] CYCLICAL CUSHINGS-DISEASE - 2 DISTINCT RHYTHMS IN A PATIENT WITH A BASOPHIL ADENOMA [J].