VALPROIC-ACID INDUCED PANCREATITIS - CASE-REPORT AND REVIEW OF THE LITERATURE

被引：35

作者：

BINEK, J ^{[1
]}

HANY, A ^{[1
]}

HEER, M ^{[1
]}

机构：

[1] KANTONSSPITAL,DEPT MED GASTROENTEROL,CH-8401 WINTERTHUR,SWITZERLAND

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1991年 / 13卷 / 06期

关键词：

DRUG-INDUCED PANCREATITIS; VALPROIC ACID; PANCREATIC PSEUDOCYST;

D O I：

10.1097/00004836-199112000-00016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report a case of pancreatitis with fatal liver failure, in a 21-year-old, mentally retarded patient, taking valproic acid (VPA) therapy, together with a review of the literature of this rare side effect. Until March 1991, only 24 cases of isolated pancreatitis and six cases (including ours) of pancreatitis with hepatic failure under VPA treatment have been published. Most of the patients were less than 20 years old, and injury to the pancreas developed during the first year of therapy in 72% of the patients, approaching a mortality of 21%. Pancreatitis associated with liver failure has a poor prognosis mainly because of the VPA hepatotoxicity. It seems that the pancreatic side effects fluctuate between two extremes: asymptomatic hyperamylasemia and fatal pancreatitis.

引用

页码：690 / 693

页数：4

共 25 条

[1]

Baskies A M, 1984, J Med Soc N J, V81, P399

[2]

BATALDEN PB, 1979, PEDIATRICS, V64, P520

[3] INAPPARENT PANCREATITIS WITH DEVELOPMENT OF A PSEUDOCYST AND CHOLESTATIC ICTERUS UNDER ANTICONVULSIVE THERAPY WITH VALPROIC ACID [J].

BRAUN, E ;

SPANNAGEL, B ;

BUNDSCHU, HD .

KLINISCHE WOCHENSCHRIFT, 1987, 65 (09) :433-436

[4]

CALLAGHAN N, 1982, DEV MED CHILD NEUROL, V24, P830

[5]

CAMFIELD PR, 1979, LANCET, V1, P1198

[6] PANCREATITIS ASSOCIATED WITH VALPROIC ACID THERAPY FOR EPILEPSY [J].

COULTER, DL ;

ALLEN, RJ .

ANNALS OF NEUROLOGY, 1980, 7 (01) :92-92

[7]

DICKINSON RG, 1985, EXP NEUROL, V33, P379

[8]

Dreifuss F E, 1988, Am J Med, V84, P34, DOI 10.1016/0002-9343(88)90055-1

[9] VALPROIC ACID HEPATIC FATALITIES - A RETROSPECTIVE REVIEW [J].

DREIFUSS, FE ;

SANTILLI, N ;

LANGER, DH ;

SWEENEY, KP ;

MOLINE, KA ;

MENANDER, KB .

NEUROLOGY, 1987, 37 (03) :379-385

[10] VALPROATE-ASSOCIATED HEPATOTOXICITY AND ITS BIOCHEMICAL-MECHANISMS [J].

EADIE, MJ ;

HOOPER, WD ;

DICKINSON, RG .

MEDICAL TOXICOLOGY AND ADVERSE DRUG EXPERIENCE, 1988, 3 (02) :85-106

← 1 2 3 →