MISONIDAZOLE - DRUG FOR TRIAL IN RADIOTHERAPY AND ONCOLOGY

被引：124

作者：

DISCHE, S ^{[1
]}

SAUNDERS, MI ^{[1
]}

FLOCKHART, IR ^{[1
]}

LEE, ME ^{[1
]}

ANDERSON, P ^{[1
]}

机构：

[1] MT VERNON HOSP,GRAY LAB,NORTHWOOD HA6 2RN,MIDDLESEX,ENGLAND

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 06期

关键词：

Misonidazole; Neurotoxicity; Plasma concentrations; Radiotherapy; Tumor concentrations;

D O I：

10.1016/0360-3016(79)90070-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Misonidazole is an hypoxic cell radiosensitizer with promise in clinical radiotherapy. The concentrations which may be achieved in plasma, in tumors and in normal tissues are discussed. The toxic effects of misonidazole are described and schemes for the safe administration in man detailed. © 1979.

引用

页码：851 / 860

页数：10

共 26 条

[1]

AWWAD HK, 1978, BRIT J CANCER, V37, P297

[2]

DAWES PJDK, 1978, BRIT J CANCER, V37, P290

[3] NEUROTOXICITY OF MISONIDAZOLE - POOLING OF DATA FROM 5 CENTERS [J].

DISCH, S ;

SAUNDERS, MI ;

ANDERSON, P ;

URTASUN, RC ;

KARCHER, KH ;

KOGELNIK, HD ;

BLEEHEN, N ;

PHILLIPS, TL ;

WASSERMAN, TH .

BRITISH JOURNAL OF RADIOLOGY, 1978, 51 (612) :1023-1024

[4]

DISCHE S, 1976, CLIN RADIOL, V27, P159, DOI 10.1016/S0009-9260(76)80138-9

[5] CLINICAL TESTING OF RADIOSENSITIZER RO 07-0582 - EXPERIENCE WITH MULTIPLE DOSES [J].

DISCHE, S ;

SAUNDERS, MI ;

LEE, ME ;

ADAMS, GE ;

FLOCKHART, IR .

BRITISH JOURNAL OF CANCER, 1977, 35 (05) :567-579

[6]

DISCHE S, 1978, BRIT J CANCER, V37, P318

[7]

DISCHE S, 1978, BRIT J CANCER, V37, P311

[8] PHARMACOKINETIC AND METABOLIC STUDIES OF HYPOXIC CELL RADIOSENSITIZER MISONIDAZOLE [J].

FLOCKHART, IR ;

LARGE, P ;

TROUP, D ;

MALCOLM, SL ;

MARTEN, TR .

XENOBIOTICA, 1978, 8 (02) :97-105

[9] SERUM CONCENTRATION MEASUREMENTS IN MAN OF RADIOSENSITIZER RO-07-0582 - SOME PRELIMINARY RESULTS [J].

FOSTER, JL ;

FLOCKHART, IR ;

DISCHE, S ;

GRAY, A ;

LENOXSMITH, I ;

SMITHEN, CE .

BRITISH JOURNAL OF CANCER, 1975, 31 (06) :679-683

[10] CLINICAL TESTING OF RADIOSENSITIZER RO-07-0582 .1. DOSE TOLERANCE, SERUM AND TUMOR CONCENTRATIONS [J].

GRAY, AJ ;

DISCHE, S ;

ADAMS, GE ;

FLOCKHART, IR ;

FOSTER, JL .

CLINICAL RADIOLOGY, 1976, 27 (02) :151-157

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