OBSERVATIONS ON ADMINISTRATION OF IRIDODIAL-7-14C TO VINCA ROSEA

被引:14
作者
BOWMAN, RM
LEETE, E
机构
[1] School of Chemistry, University of Minnesota, Minneapolis, MN
关键词
D O I
10.1016/S0031-9422(00)86346-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has been suggested that iridodial is a biosynthetic intermediate between geraniol and loganin, which is a precursor of the non-tryptophan derived portion of vindoline, catharanthine, ajmalicine, and other indole alkaloids found in Vinca rosea. Iridodial-7-14C was synthesized from ethyl iodide-1-14C and fed to V. rosea plants, which afforded vindoline having negligible activity. It thus seems unlikely that iridodial is a precursor of loganin. © 1969.
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页码:1003 / +
页数:1
相关论文
共 31 条
[1]   BIOSYNTHESIS OF METHYLCYCLOPENTANE MONOTERPENOIDS .I. SKYTANTHUS ALKALOIDS [J].
AUDA, H ;
JUNEJA, HR ;
EISENBRAUN, EJ ;
WALLER, GR ;
KAYS, WR ;
APPEL, HH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (10) :2476-+
[2]  
BATTERSBY A. R., 1967, PURE APPL CHEM, V14, P117, DOI 10.1351/pac196714010117
[3]   MECHANISM OF INDOLE ALKALOID BIOSYNTHESIS [J].
BATTERSBY, AR ;
BYRNE, JC ;
KAPIL, RS ;
MARTIN, JA ;
PAYNE, TG ;
AGRIGONI, D ;
LOEW, P .
CHEMICAL COMMUNICATIONS, 1968, (16) :951-+
[4]   FURTHER EVIDENCE CONCERNING BIOSYNTHESIS OF INDOLE ALKALOIDS AND QUININE [J].
BATTERSBY, AR ;
BROWN, RT ;
KAPIL, RS ;
KNIGHT, JA ;
MARTIN, JA ;
PLUNKETT, AO .
CHEMICAL COMMUNICATIONS, 1966, (23) :888-+
[5]   LOGANIN AS PRECURSOR OF INDOLE ALKALOIDS [J].
BATTERSBY, AR ;
KAPIL, RS ;
MARTIN, JA ;
MO, L .
CHEMICAL COMMUNICATIONS, 1968, (03) :133-+
[6]   STRUCTURE STEREOCHEMISTRY AND BIOSYNTHESIS OF LOGANIN [J].
BATTERSBY, AR ;
KAPIL, RS ;
SOUTHGAT.R .
CHEMICAL COMMUNICATIONS, 1968, (03) :131-+
[7]   BIOSYNTHESIS OF INDOLE ALKALOIDS FROM A MONOTERPENE [J].
BATTERSBY, AR ;
BROWN, RT ;
KNIGHT, JA ;
MARTIN, JA ;
PLUNKETT, AO .
CHEMICAL COMMUNICATIONS, 1966, (12) :346-+
[8]   BIOSYNTHESIS OF INDOLE ALKALOIDS [J].
BATTERSBY, AR ;
BROWN, RT ;
KAPIL, RS ;
PLUNKETT, AO ;
TAYLOR, JB .
CHEMICAL COMMUNICATIONS, 1966, (02) :46-+
[9]   ROLE OF LOGANIN IN BIOSYNTHESIS OF INDOLE ALKALOIDS [J].
BATTERSBY, AR ;
BROWN, RT ;
KAPIL, RS ;
MARTIN, JA ;
PLUNKETT, AO .
CHEMICAL COMMUNICATIONS, 1966, (23) :890-+
[10]  
BIRCH AJ, 1950, ANNU REP PROGR CHEM, V47, P192