Detection and Quantification of Free Radicals in Peroxisomal Disorders: A Comparative Study with Oxidative Stress Parameters

被引：1

作者：

Abd-ElMaksoud, Sohair Abd-El Mawgood ^{[1
]}

El-Bassyouni, Hala ^{[2
]}

Afifi, Hanan ^{[2
]}

Thomas, Manal Micheal ^{[2
]}

Ibrahim, Alshaymaa Ahmed ^{[1
]}

Shalaby, Aliaa ^{[1
]}

Hamid, Tamer Ahmed Abdel ^{[3
]}

Hamid, Nehal Abdel ^{[4
]}

El-Ghobary, Hany ^{[5
]}

机构：

[1] Natl Res Ctr, Dept Clin Pathol, Giza, Egypt

[2] Natl Res Ctr, Dept Clin Genet, Giza, Egypt

[3] Cairo Univ, Fac Med, Dept Paediat, Giza, Egypt

[4] Natl Res Ctr, Dept Paediat, Giza, Egypt

[5] Cairo Univ, Fac Med, Dept Clin & Chem Pathol, Giza, Egypt

来源：

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2015年 / 9卷 / 11期

关键词：

Malondialdehyde; Nitric oxide; Superoxide dismutase;

D O I：

10.7860/JCDR/2015/15629.6788

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Free radicals have been thought to participate in pathogenesis of peroxisomal disorders. Objective: The aim of the work is to detect free oxide radicals in blood of patients with peroxisomal disorders and to study their relation with various oxidative stress parameters. Materials and Methods: Twenty patients with peroxisomal disorders and 14 age and sex matched healthy subjects were included in the study. Patients with peroxisomal disorders were subdivided according to diagnosis into peroxisomal biogenesis disorders and single enzyme deficiency. Oxidative stress was evaluated in both patients and control subjects by assessment of free radicals, malondialdehyde, nitric oxide metabolites and superoxide dismutase. Results: There was increase in free radicals, malondialdehyde, nitric oxide metabolites in patients compared with control subjects. However, there was decrease in superoxide dismutase levels in patients compared with control subjects. Conclusion: We concluded that there is excess free radicals production accompanied with decrease in antioxidant defenses in patients with peroxisomal disorders. These results strongly support a role of free radicals in the pathophysiology of peroxisomal disorders and strengthen the importance of oxidative stress phenomenon in peroxisomal disorders pathogenesis.

引用

页码：SC17 / SC20

页数：4

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