RAPID PROGRESSION TO DISEASE IN AFRICAN SEX WORKERS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION

被引：118
作者：
ANZALA, OA
NAGELKERKE, NJD
BWAYO, JJ
HOLTON, D
MOSES, S
NGUGI, EN
NDINYAACHOLA, JO
PLUMMER, FA
机构：
[1] UNIV NAIROBI,WHO,COLLABORATING CTR STD RES & TRAINING,DEPT COMMUNITY HLTH,NAIROBI,KENYA
[2] KENYA GOVT MED RES CTR,CTR MICROBIOL RES,NAIROBI,KENYA
[3] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG,MB,CANADA
[4] UNIV MANITOBA,DEPT MED,WINNIPEG,MB,CANADA
[5] UNIV MANITOBA,DEPT COMMUNITY HLTH SCI,WINNIPEG,MB,CANADA
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1093/infdis/171.3.686
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
引用
收藏
页码：686 / 689
页数：4
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