Sequence analysis of the Schizosaccharomyces pombe homologue of the CDC3 gene in Saccharomyces cerevisiae

Saccharomyces cerevisiae has a highly ordered ring of filaments that lies just inside the cytoplasmic membrane in the region of the mother-bud neck Mutants defective in any one of the four cell-division cycle genes (CDC3, CDC10, CDC11, CDC12) fail to form these filaments and exhibit a pleiotropic phenotype that includes failure to complete cytokinesis and abnomal bud growth. However, the role of the filament is not clear. In order to find out the role of filament, the similar gene in S. pombe (called cdc103(+)) to the CDC3 was cloned and sequenced. Here I report the sequence analysis of the cdc103(+). Comparison of the predicted amino acid sequences of cdc103(+) and CDC3 revealed that they share significant similarity (43% identity and 56% identity or similarity) to each other.