IN-VITRO AND IN-VIVO ANTITUMORAL PHENANTHRENES FROM THE AERIAL PARTS OF DENDROBIUM NOBILE

被引：160
作者：
LEE, YH
PARK, JD
BAEK, NI
KIM, SI
AHN, BZ
机构：
[1] KOREA GINSENG & TOBACCO RES INST,NAT PROD LAB,TAEJON 305345,SOUTH KOREA
[2] CHUNGNAM NATL UNIV,COLL PHARM,TAEJON 305764,SOUTH KOREA
来源：
PLANTA MEDICA | 1995年 / 61卷 / 02期
关键词：
D O I：
10.1055/s-2006-958043
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.
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页码：178 / 180
页数：3
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