EVIDENCE FOR CROSS-PATHWAY REGULATION OF METABOLIC GENE-EXPRESSION IN PLANTS

被引:72
作者
GUYER, D [1 ]
PATTON, D [1 ]
WARD, E [1 ]
机构
[1] CIBA AGR BIOTECHNOL,RES TRIANGLE PK,NC 27709
关键词
D O I
10.1073/pnas.92.11.4997
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression of eight genes involved in the biosynthesis of aromatic amino acids, histidine, lysine, and purines. A decrease in expression of glutamine synthetase was also observed. Addition of histidine eliminated the gene-regulating effects of the inhibitor, demonstrating that the changes in gene expression resulted from histidine-pathway blockage. These results show that plants are capable of cross-pathway metabolic regulation.
引用
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页码:4997 / 5000
页数:4
相关论文
共 37 条
[1]  
BREARS T, 1991, GENETIC ENG, V13, P221
[2]   INCREASED ACTIVITY OF TRYPTOPHAN BIOSYNTHETIC ENZYMES IN HISTIDINE MUTANTS OF NEUROSPORA CRASSA [J].
CARSIOTIS, M ;
LACY, AM .
JOURNAL OF BACTERIOLOGY, 1965, 89 (06) :1472-+
[3]   CROSS-PATHWAY REGULATION - HISTIDINE-MEDIATED CONTROL OF HISTIDINE, TRYPTOPHAN, AND ARGININE BIOSYNTHETIC ENZYMES IN NEUROSPORA-CRASSA [J].
CARSIOTIS, M ;
JONES, RF ;
WESSELING, AC .
JOURNAL OF BACTERIOLOGY, 1974, 119 (03) :893-898
[4]   PROLINE BIOSYNTHESIS AND OSMOREGULATION IN PLANTS [J].
DELAUNEY, AJ ;
VERMA, DPS .
PLANT JOURNAL, 1993, 4 (02) :215-223
[5]   CPC-1, THE GENERAL REGULATORY GENE FOR GENES OF AMINO-ACID BIOSYNTHESIS IN NEUROSPORA-CRASSA, IS DIFFERENTIALLY EXPRESSED DURING THE ASEXUAL LIFE-CYCLE [J].
EBBOLE, DJ ;
PALUH, JL ;
PLAMANN, M ;
SACHS, MS ;
YANOFSKY, C .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :928-934
[6]   CLONING AND EXPRESSION IN YEAST OF A HIGHER-PLANT CHORISMATE MUTASE - MOLECULAR-CLONING, SEQUENCING OF THE CDNA AND CHARACTERIZATION OF THE ARABIDOPSIS-THALIANA ENZYME EXPRESSED IN YEAST [J].
EBERHARD, J ;
RAESECKE, HR ;
SCHMID, J ;
AMRHEIN, N .
FEBS LETTERS, 1993, 334 (02) :233-236
[7]   DIRECT GENETIC SELECTION OF A MAIZE CDNA FOR DIHYDRODIPICOLINATE SYNTHASE IN AN ESCHERICHIA-COLI DAPA- AUXOTROPH [J].
FRISCH, DA ;
TOMMEY, AM ;
GENGENBACH, BG ;
SOMERS, DA .
MOLECULAR & GENERAL GENETICS, 1991, 228 (1-2) :287-293
[8]  
GOTTESMAN S, 1984, ANNU REV GENET, V18, P415
[9]  
HAWKES TR, 1993, IMIDAZOLE GLYCEROL P, V2, P739
[10]   PRIMARY SITE OF ACTION OF AMITROLE IN ARABIDOPSIS-THALIANA INVOLVES INHIBITION OF ROOT ELONGATION BUT NOT OF HISTIDINE OR PIGMENT BIOSYNTHESIS [J].
HEIM, DR ;
LARRINUA, IM .
PLANT PHYSIOLOGY, 1989, 91 (03) :1226-1231