EXPRESSION OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) IN ANAPLASTIC CARCINOMA OF THE THYROID

被引：30
作者：
SUGAWARA, I
ARAI, T
YAMASHITA, T
YOSHIDA, A
MASUNAGA, A
ITOYAMA, S
机构：
[1] TOKYO WOMENS MED COLL,DEPT ENDOCRINE SURG,TOKYO 162,JAPAN
[2] KANAGAWA CANC CTR,YOKOHAMA,KANAGAWA,JAPAN
来源：
CANCER LETTERS | 1994年 / 82卷 / 02期
关键词：
ANAPLASTIC CARCINOMA OF THE THYROID; MRP MESSENGER-RNA; MULTIDRUG RESISTANCE; MDR1;
D O I：
10.1016/0304-3835(94)90010-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although the incidence is very low, the prognosis of anaplastic carcinoma of the thyroid is very poor regardless of the results of various therapeutic trials. We found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of the mdr1 and its gene product, P-glycoprotein. Therefore, expression of multidrug resistance-associated protein (MRP) mRNA was examined in 11 anaplastic thyroid carcinomas and eight anaplastic thyroid carcinoma cell lines. High MRP mRNA expression was recognized in 7/11 and 8/8, respectively. Our results may contribute to elucidation of the mechanism of anti-cancer drug resistance in this neoplasm.
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页码：185 / 188
页数：4
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