PECULIARITIES OF THE CLASTOGENIC PROPERTIES OF CHRYSOTILE-ASBESTOS FIBERS AND ZEOLITE PARTICLES

被引：7

作者：

DURNEV, AD ^{[1
]}

DAUGELDAUGE, NO ^{[1
]}

KORKINA, LG ^{[1
]}

SEREDENIN, SB ^{[1
]}

机构：

[1] SECOND MOSCOW MED INST,117437 MOSCOW,RUSSIA

来源：

MUTATION RESEARCH | 1993年 / 319卷 / 04期

关键词：

ACTIVE OXYGEN SPECIES; CHROMOSOME ABERRATIONS; CHRYSOTILE-ASBESTOS; ZEOLITE;

D O I：

10.1016/0165-1218(93)90019-A

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It has been established that chrysotile-asbestos fibers and zeolite particles induce chromosome aberrations in human lymphocytes from whole blood cultures, peritoneal fluid cells and bone marrow cells of mice. It is shown that the level of cytogenetic response from the intraperitoneal administration of chrysotile-asbestos fibers and zeolite particles depends on the time of their exposure. Further, it is shown that SOD eliminates the cytogenetic effect of chrysotile-asbestos fibers, while catalase inhibits that of zeolite particles. Recommendations concerning testing for the mutagenic properties of mineral fibers and particles are given, and possible mechanisms of their damaging effects are discussed.

引用

页码：303 / 308

页数：6

共 23 条

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