THE ROLE OF APOPTOTIC AND NECROTIC PROCESSES IN CYTOLYSIS MEDIATED BY LAK CELLS WITH DIFFERENT PHENOTYPES

被引：10

作者：

SASHCHENKO, LP ^{[1
]}

KABANOVA, OD ^{[1
]}

BLISHCHENKO, LY ^{[1
]}

LUKJIANOVA, TI ^{[1
]}

SATPAEV, DK ^{[1
]}

CHERTOV, OY ^{[1
]}

GNUCHEV, NV ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,SHEMYAKIN INST BIOORGAN CHEM,MOSCOW,RUSSIA

来源：

FEBS LETTERS | 1993年 / 335卷 / 02期

关键词：

LAK CELL; APOPTOSIS; NECROSIS;

D O I：

10.1016/0014-5793(93)80744-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of necrotic and apoptotic pathways in cytolysis mediated by LAK cells was studied. The contribution of necrotic and apoptotic processes to cytolysis depends both on the LAK cells' phenotype and the type of target cells. CD16+/CD8+/CD3- LAK cells induced necrosis of K562 and L929 target cells. The cell death induced by CD3+/CD8+/CD16- LAK cells was found to include features of apoptotic and necrotic processes.

引用

页码：270 / 272

页数：3

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