TUMOR SUPPRESSION IN XIPHOPHORUS BY AN ACCIDENTALLY ACQUIRED PROMOTER

被引：96
作者：
ADAM, D
DIMITRIJEVIC, N
SCHARTL, M
机构：
[1] MAX PLANCK INST BIOCHEM, GENZENTRUM, W-8033 MARTINSRIED, GERMANY
[2] UNIV WURZBURG, THEODOR BOVERI INST BIOWISSENSCH, W-8700 WURZBURG, GERMANY
来源：
SCIENCE | 1993年 / 259卷 / 5096期
关键词：
D O I：
10.1126/science.8430335
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.
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页码：816 / 819
页数：4
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