TUMOR SUPPRESSION IN XIPHOPHORUS BY AN ACCIDENTALLY ACQUIRED PROMOTER

被引：96

作者：

ADAM, D

DIMITRIJEVIC, N

SCHARTL, M

机构：

[1] MAX PLANCK INST BIOCHEM, GENZENTRUM, W-8033 MARTINSRIED, GERMANY

[2] UNIV WURZBURG, THEODOR BOVERI INST BIOWISSENSCH, W-8700 WURZBURG, GERMANY

来源：

SCIENCE | 1993年 / 259卷 / 5096期

关键词：

D O I：

10.1126/science.8430335

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.

引用

页码：816 / 819

页数：4

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