CYCLIC STRETCH INCREASES ALKALINE-PHOSPHATASE ACTIVITY OF OSTEOBLAST-LIKE CELLS - A ROLE FOR PROSTAGLANDIN-E(2)

被引：34
作者：
NISHIOKA, S [1 ]
FUKUDA, K [1 ]
TANAKA, S [1 ]
机构：
[1] KINKI UNIV, SCH MED, DEPT ORTHOPAED SURG, OHNOHIGASHI 377-2, OSAKA, OSAKA 589, JAPAN
来源：
BONE AND MINERAL | 1993年 / 21卷 / 02期
关键词：
OSTEOBLAST; PROSTAGLANDIN-E(2); CYCLIC STRETCH; ALKALINE PHOSPHATASE;
D O I：
10.1016/S0169-6009(08)80016-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effects of applied cyclic stretch on osteoblast-like cells using a computerized, pressure-operated instrument that physically deforms the cells. Cyclic stretch increased DNA and collagenous protein synthesis and enhanced alkaline phosphatase activity in the cells. These effects were considered to be regulated through prostaglandin E2 production since this stretch reduced the levels of prostaglandin E2 in the medium and when prostaglandin E2 was added exogenously, there was a significant decrease in the alkaline phosphatase activity.
引用
收藏
页码：141 / 150
页数：10
相关论文
共 50 条
  • [41] Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: Potential association between collagenase expression and changes in alkaline phosphatase phenotype
    Shiga, M
    Kapila, YL
    Zhang, Q
    Hayami, T
    Kapila, S
    JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (01) : 67 - 77
  • [42] PROSTAGLANDIN-F2-ALPHA ACTIVATES PHOSPHOLIPASE-D INDEPENDENTLY FROM ACTIVATION OF PROTEIN-KINASE-C IN OSTEOBLAST-LIKE CELLS
    KOZAWA, O
    SUZUKI, A
    KOTOYORI, J
    TOKUDA, H
    WATANABE, Y
    ITO, Y
    OISO, Y
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 55 (03) : 373 - 379
  • [43] Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like-MC3T3-E1 cells
    Hanai, Yoshiteru
    Tokuda, Haruhiko
    Ishisaki, Akira
    Matsushima-Nishiwaki, Rie
    Nakamura, Norimi
    Yoshida, Minoru
    Takai, Shinji
    Ohta, Toshiki
    Kozawa, Osamu
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 251 (1-2) : 42 - 48
  • [44] EFFECT OF BETA-ALANYL-L-HISTIDINATO ZINC ON OSTEOBLASTIC MC3T3-E1 CELLS - INCREASES IN ALKALINE-PHOSPHATASE AND PROLIFERATION
    YAMAGUCHI, M
    OHTAKI, J
    PHARMACOLOGY, 1991, 43 (04) : 225 - 232
  • [45] Effect of the aminosteroid U73122 on prostaglandin E2 production in a murine clonal osteoblast-like cell line, MC3T3-E1
    Leis, HJ
    Köfeler, H
    Raspotnig, G
    Zach, D
    Fauler, G
    Windischhofer, W
    BIOCHEMICAL PHARMACOLOGY, 2000, 60 (07) : 899 - 904
  • [46] Regulation of adenosine 3′,5′-cyclic monophosphate (cAMP) accumulation in UMR-106 osteoblast-like cells:: Role of cAMP-phosphodiesterase and cAMP efflux
    Ahlström, M
    Lamberg-Allardt, C
    BIOCHEMICAL PHARMACOLOGY, 1999, 58 (08) : 1335 - 1340
  • [47] Dopamine down-regulates activity of alkaline phosphatase in Drosophila: The role of D2-like receptors
    Bogomolova, E. V.
    Rauschenbach, I. Yu.
    Adonyeva, N. V.
    Alekseev, A. A.
    Faddeeva, N. V.
    Gruntenko, N. E.
    JOURNAL OF INSECT PHYSIOLOGY, 2010, 56 (09) : 1155 - 1159
  • [48] Effect of estrogen and 1α,25(OH)2-vitamin D3 on the activity and growth of human primary osteoblast-like cells in vitro
    Chen, FP
    Lee, N
    Wang, KC
    Soong, YK
    Huang, KE
    FERTILITY AND STERILITY, 2002, 77 (05) : 1038 - 1043
  • [49] EFFECT OF RETINOIC ACID ON THE PROLIFERATION AND ALKALINE-PHOSPHATASE ACTIVITY OF OSTEOBLASTIC MC3T3-E1 CELLS BY MODULATING THE RELEASE OF LOCAL REGULATORS FROM MONOCYTES
    KAJI, H
    SUGIMOTO, T
    KANATANI, M
    KANO, J
    FUKASE, M
    CHIHARA, K
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1995, 103 (05) : 297 - 302
  • [50] Transcriptional regulation of alpha 2(1) collagen gene expression by fibroblast growth factor-2 in MC3T3-E1 osteoblast-like cells
    Fang, MA
    Glackin, CA
    Sadhu, A
    McDougall, S
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2001, 80 (04) : 550 - 559
12345