CYCLIC STRETCH INCREASES ALKALINE-PHOSPHATASE ACTIVITY OF OSTEOBLAST-LIKE CELLS - A ROLE FOR PROSTAGLANDIN-E(2)

被引：34
作者：
NISHIOKA, S [1 ]
FUKUDA, K [1 ]
TANAKA, S [1 ]
机构：
[1] KINKI UNIV, SCH MED, DEPT ORTHOPAED SURG, OHNOHIGASHI 377-2, OSAKA, OSAKA 589, JAPAN
来源：
BONE AND MINERAL | 1993年 / 21卷 / 02期
关键词：
OSTEOBLAST; PROSTAGLANDIN-E(2); CYCLIC STRETCH; ALKALINE PHOSPHATASE;
D O I：
10.1016/S0169-6009(08)80016-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effects of applied cyclic stretch on osteoblast-like cells using a computerized, pressure-operated instrument that physically deforms the cells. Cyclic stretch increased DNA and collagenous protein synthesis and enhanced alkaline phosphatase activity in the cells. These effects were considered to be regulated through prostaglandin E2 production since this stretch reduced the levels of prostaglandin E2 in the medium and when prostaglandin E2 was added exogenously, there was a significant decrease in the alkaline phosphatase activity.
引用
收藏
页码：141 / 150
页数：10
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