DEBRISOQUINE POLYMORPHISM - MECHANISM FOR VERY RAPID OXIDATIVE PHENOTYPE

被引：5
作者：
AGUNDEZ, JAG
BENITEZ, J
机构：
来源：
LANCET | 1993年 / 341卷 / 8846期
关键词：
D O I：
10.1016/0140-6736(93)90455-P
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：689 / 689
页数：1
相关论文
共 7 条
[1]   DEBRISOQUIN OXIDATION POLYMORPHISM IN A SPANISH POPULATION [J].
BENITEZ, J ;
LLERENA, A ;
COBALEDA, J .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 44 (01) :74-77
[2]  
BERTILSSON, 1993, LANCET, V341, P63
[3]   DEBRISOQUINE SPARTEINE HYDROXYLATION GENOTYPE AND PHENOTYPE - ANALYSIS OF COMMON MUTATIONS AND ALLELES OF CYP2D6 IN A EUROPEAN POPULATION [J].
BROLY, F ;
GAEDIGK, A ;
HEIM, M ;
EICHELBAUM, M ;
MORIKE, K ;
MEYER, UA .
DNA AND CELL BIOLOGY, 1991, 10 (08) :545-558
[4]   CLINICAL-SIGNIFICANCE OF THE SPARTEINE-DEBRISOQUINE OXIDATION POLYMORPHISM [J].
BROSEN, K ;
GRAM, LF .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (06) :537-547
[5]   PREDICTION OF PHENOTYPE FOR ACETYLATION AND FOR DEBRISOQUINE HYDROXYLATION BY DNA-TESTS IN HEALTHY-HUMAN VOLUNTEERS [J].
GRAF, T ;
BROLY, F ;
HOFFMANN, F ;
PROBST, M ;
MEYER, UA ;
HOWALD, H .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 43 (04) :399-403
[6]   GENOTYPING OF POOR METABOLIZERS OF DEBRISOQUINE BY ALLELE-SPECIFIC PCR AMPLIFICATION [J].
HEIM, M ;
MEYER, UA .
LANCET, 1990, 336 (8714) :529-532
[7]   IDENTIFICATION OF A NEW VARIANT CYP2D6 ALLELE LACKING THE CODON ENCODING LYS-281 - POSSIBLE ASSOCIATION WITH THE POOR METABOLIZER PHENOTYPE [J].
TYNDALE, R ;
AOYAMA, T ;
BROLY, F ;
MATSUNAGA, T ;
INABA, T ;
KALOW, W ;
GELBOIN, HV ;
MEYER, UA ;
GONZALEZ, FJ .
PHARMACOGENETICS, 1991, 1 (01) :26-32
1