THE INVENTION OF RADICAL REACTIONS .25. A CONVENIENT METHOD FOR THE SYNTHESIS OF THE ACYL DERIVATIVES OF N-HYDROXYPYRIDINE-2-THIONE

被引：70
作者：
BARTON, DHR
SAMADI, M
机构：
[1] Department of Chemistry, Texas A and M University, College Station
来源：
TETRAHEDRON | 1992年 / 48卷 / 35期
关键词：
N-HYDROXYPYRIDINE-2-THIONE ACYL DERIVATIVES; TRIBUTYLPHOSPHINE; RADICAL CHEMISTRY;
D O I：
10.1016/S0040-4020(01)88249-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of the readily available di-N-oxide- of 2-thiopyridine disulfide 6 with tributylphosphine in the presence of a carboxylic acid provides a convenient and high yielding synthesis of the acyl derivatives 2 of N-hydroxy-2-thio-pyridone. Application of this procedure to the acids 17 and 18 gave, after irradiation in the presence of t-butylthiol, the desired decarbaxylated derivatives in high (>90%) yield.
引用
收藏
页码：7083 / 7090
页数：8
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