CONSERVATION OF HPV-16 E6/E7 ORF SEQUENCES IN A CERVICAL-CARCINOMA

被引：20
|
作者：
CONE, RW
MINSON, AC
SMITH, MR
MCDOUGALL, JK
机构：
[1] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA
[2] FIRST HILL WOMENS CLIN, SEATTLE, WA USA
来源：
JOURNAL OF MEDICAL VIROLOGY | 1992年 / 37卷 / 02期
关键词：
HUMAN PAPILLOMAVIRUS; GENITAL; CANCER;
D O I：
10.1002/jmv.1890370205
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.
引用
收藏
页码：99 / 107
页数：9
相关论文
共 50 条
  • [41] Oncogene lineages of human papillomavirus type 16 E6, E7 and E5 in preinvasive and invasive cervical squamous cell carcinoma
    Hu, XR
    Pang, TY
    Guo, ZM
    Pontén, J
    Nistér, M
    Afink, GB
    JOURNAL OF PATHOLOGY, 2001, 195 (03): : 307 - 311
  • [42] HPV E6/E7 mRNA in situ hybridization in endocervical adenocarcinoma: implications for prognosis and diagnosis
    Luo, Rong-Zhen
    Chen, Shu-Lin
    Li, Mei
    Li, Yue
    Yang, Xia
    Liu, Li-Li
    CANCER CELL INTERNATIONAL, 2021, 21 (01)
  • [43] Detection of HPV E6/E7 mRNA in the diagnosis of cervical cancer and precancerous lesions after kidney transplantation
    Sun, Jing
    Yue, Yanna
    Li, Rong
    Sun, Qian
    Hu, Chaofeng
    Ge, Xiaohong
    Guan, Qingyan
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 13 (06): : 7312 - 7317
  • [44] Fusion of CTLA-4 with HPV16 E7 and E6 Enhanced the Potency of Therapeutic HPV DNA Vaccine
    Gan, Lili
    Jia, Rong
    Zhou, Lili
    Guo, Jihua
    Fan, Mingwen
    PLOS ONE, 2014, 9 (09):
  • [45] Cervical cancer screening: which HPV test should be used-L1 or E6/E7?
    Tjalma, W. A. A.
    Depuydt, C. E.
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2013, 170 (01) : 45 - 46
  • [46] Viral load and interaction of HPV oncoprotein E6 and E7 with host cellular markers in the progression of cervical cancer
    Mir, Bilal Ahmad
    Rahaman, P. F.
    Ahmad, Arif
    AIMS MOLECULAR SCIENCE, 2021, 8 (03): : 184 - 192
  • [47] RETRACTED: Predictive Value of HPV E6/E7 mRNA Detection on the Outcome of Cervical LSIL (Retracted Article)
    Cao, Limei
    He, Ping
    Yang, Jun
    Long, Xin
    Chen, Yanqiu
    Yan, Li
    Zhou, Deping
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [48] The difference of transcriptome of HPV-infected patients contributes more to the occurrence of cervical cancer than the mutations of E6 and E7 genes in HPV16
    Zhang, Lihui
    Li, Mengyuan
    Yuan, Feiyan
    Jiang, Jingyuan
    Zhang, Xinmin
    MEDICINE, 2024, 103 (03) : E36822
  • [49] Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions
    Hui, Chang
    Bai, Huimin
    Liu, Jun
    Lu, Xuerong
    Wang, Shuzhen
    Zhang, Zhenyu
    Jin, Mulan
    Wang, Yue
    Liu, Yuzhen
    DIAGNOSTIC PATHOLOGY, 2021, 16 (01)
  • [50] Quantitative polymerase chain reaction-based detection of HPV 16 E6 and E7 DNA in oral squamous cell carcinoma
    Thammaiah, Smitha
    Venkobarao, Mohan C.
    Sathyavanthan, Hemavathy
    Mirnalini, Angeline S.
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2018, 47 (09) : 873 - 879
12345