LOGISTIC DISCRIMINANT-ANALYSIS OF LIPIDS AND APOLIPOPROTEINS IN A POPULATION OF CORONARY-BYPASS PATIENTS AND THE SIGNIFICANCE OF APOLIPOPROTEIN-C-III AND APOLIPOPROTEIN-E

被引：62

作者：

CHIVOT, L

MAINARD, F

BIGOT, E

BARD, JM

AUGET, JL

MADEC, Y

FRUCHART, JC

机构：

[1] FAC PHARM NANTES,BIOCHIM PHARMACEUT LAB,1 RUE GASTON VEIL,F-44035 NANTES,FRANCE

[2] INST PASTEUR,SERLIA,LILLE,FRANCE

[3] FAC PHARM NANTES,BIOMATH & BIOSTAT LAB,NANTES,FRANCE

[4] CHU NANTES,HOP GUILLAUME & RENE LAENNEC,BIOCHIM LAB B,NANTES,FRANCE

来源：

ATHEROSCLEROSIS | 1990年 / 82卷 / 03期

关键词：

Apolipoproteins A-I; B; C-III; E; Coronary bypass; Lipids; Logistic discriminant analysis;

D O I：

10.1016/0021-9150(90)90042-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The lipid and apolipoprotein states of 74 men (mean age 49.96 ± 5.9 years) were studied 24 h before coronary bypass surgery and their results were compared with those of a control group of 78 men (mean age 48.88 ± 5.41 years). Apolipoproteins C-III (apo C-III) and E (apo E) were determined in particles with (LpB) and without (nonLpB) apo B separated using a concanavalin A reagent. Apo C-111 was significantly increased in LpB particles (P < 0.001), and apo E in LpB (P < 0.001) and nonLpB (P < 0.001) particles. The significant variables selected in logistic discriminant stepwise analysis were total cholesterol/HDLcholesterol, apo E-nonLpB and apo C-III-LpB. This last parameter, which is more discriminant than triglycerides, provides a more specific indication of dyslipoproteinemia in coronary bypass patients; in association with the other two variables, it significantly improved the percentage of correctly classified individuals. © 1990.

引用

页码：205 / 211

页数：7

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